I am so excited. I have worked up to this exceedingly gradually. My secret is I use metrogel every single day, always use only pure mineral sunscreen, and add a drop of licorice extract (an anti-irritant) to my retinol products. I started with a retinol moisturizer (at .01% retinol) and even then I could only use it every third day. Then I went to every other day, and finally, to every day. Then I started layering over that a retinol serum (at .1% retinol), starting with every other day and going to daily. I am finally able to layer a .5% retinol product over my retinol moisturizer and my skin is perfectly clear, no redness, no irritation, and no papules! I am psyched!!