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Hey beauty brains!Have been listening to your broadcasts and reading in this forum, enjoyed it very much, so please continue and thanks:)three questions please:I am almost exclusively into DIY. Read a lot of scary things about TOO low hyaluronic acid molecular weight- causing inflamation and eventually aging of the skin…on the other hand , read that hight molecular weight of HA doesn’t penetrate the skin at all- but that on the other hand does help with moisturising and some other thing that LMW doesn’t. so my conclusion is that its best to combine the two. Cant understand everything in the studies and really need your professional help. Is it really best to combine LMW with HMW – to the biggest veriety of benefits, or does LMW provide all?and the more important questions – what kda/ daltons should optimal LMW HA be – for it to penetrate the skin effectively, but on the same time , that I can be sure will NOT cause any inflamation? is 50 kda safe for sure and really the optimal number?and last- what is the optimal kda of HIGH molecular weight HA for the anti aging purposes I mentiond?Hope you understood me and that you can answer all, thank’s in advance
Hey there! If you binge listened you may have already seen/heard this show: Is hyaluronic acid a good anti-aging ingredient? Episode 75
We included pretty much everything we know about HA in this article.I’ve NEVER heard that low MW HA is bad for skin. It sounds like BS to me but I’d like to check it out. Do you have a link to a reference where you read about this?Yes, I have listened to your broadcasts on the subject – very informative scientific data! The problem is I can’t figure out myself what are (based on the existing studies) the recommended and safe- from-causing-inflammatory-response molecular weights (high- which is safe anyway I think, and low – which needs to penatrate, but can be not safe).
I am copying her some of the links I found (all the links , as far as I understood) refer to objective studies) :http://www.woundsresearch.com/article/hyaluronic-acid-inflammation-and-tissue-regeneration
https://personal-care.evonik.com/product/personal-care/Documents/sofw-hyacare-50.pdf
http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.32760/abstract;jsessionid=061D050439536CBC9CD2BE528790BCA2.f03t04
(this one i did not understand)
https://www.karger.com/Article/Pdf/324296Yes, I have listened to your broadcasts on the subject – very informative scientific data! The problem is I can’t figure out myself what are (based on the existing studies) the recommended and safe- from-causing-inflammatory-response molecular weights (high- which is safe anyway I think, and low – which needs to penatrate, but can be not safe).
I am copying her some of the links I found (all the links , as far as I understood) refer to objective studies) :http://www.woundsresearch.com/article/hyaluronic-acid-inflammation-and-tissue-regeneration
https://personal-care.evonik.com/product/personal-care/Documents/sofw-hyacare-50.pdf
(this one i did not understand)
https://www.karger.com/Article/Pdf/324296Wow, thanks for sharing. That’s quite a rabbit hole you’ve fallen into regarding HA. I scanned the links you provided but it would take days/hours/weeks to fully vet them. My first impression is that the research showing the LMW HA causes an inflammatory response is NOT based on the topical application of creams/lotions containing LMW HA. So it’s really hard to tell how much of a problem this really is.
If this bugs you so much, I suggest just saying away from HA as an ingredient. (At least the Low MW version.) there are plenty of other moisturizers you can use.Oh, no, no need to read it all…I think most are refering to one or two studies anyway…I just brought multipul sourses… ( sometimes only read conclusios or scanned for key words myself:) ) .I think the maine study ( the one most are refering to) was topical actualy (and some of the commercial skincare sites that talk about this, point to topical studies as well when they mention the 50 kda number). I think this study is the one quated here (you can check out the Results and Discussion pert) https://personal-care.evonik.com/product/personal-care/Documents/sofw-hyacare-50.pdfI am just confused now comparing it with the data especially in the remark I pointed out here, about even 50 kda causing inflamation – is that author correct? because most sites -I think- as I said, repeat the study that talks about 50 kda being the best in the LMW category…Could you refer to that?also, I would like understand which is the optimal high molecular kda (in topical effect), I didnt get the studies conclusion abot this…HA is one ,if not the best ingredients out there, for the purposes I am looking for…wouldn’t want to give the LMW up, as it is the kind that has actual ability to penetrate into deeper levels…Do you think you will you have any answer on these two points?
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This one I don’t understand as well, but please notice the author’s (dr john’s comment to stephan , on the bottom – which (if I understand correctly ) says that EVEN 50 KDA CAUSE INFLAMMATORY RESPONSE (I tried to copy it but it didnt upload) – http://barefacedtruth.com/2015/03/31/hyaluronic-acid-yes-size-does-matter/